Massive perinatal left ventricle infarction treated with tissue plasminogen activator: No ECMO – A case report

Buysse, J., Khan, R., Aldoss, O., Vijayakumar, N., Karimi, M., Mohammad Nijres, B. | JNPM 2022;

Abstract: Neonatal myocardial infarction due to coronary thrombus is a rare cause of acute heart failure and is associated with high morbidity and mortality. We present a rare case of a full-term newborn who developed coronary artery thrombus treated with intracoronary recombinant tissue plasminogen activator infusion while undergoing therapeutic hypothermia. Also, we describe a unique treatment strategy to support systemic circulation sparing the patient from neonatal extracorporeal membrane oxygenation and its complications. Neonatal myocardial infarction should be suspected and ruled out in sick newborns.

*Corresponding Author: 

Janelle Buysse, Division of Cardiology, Department of Pediatrics, Stead Family Children’s Hospital, The University of Iowa, 1010 BT, 200 Hawkins Drive, Iowa City, IA 52242, USA. E-mail: