A rare case of fetal extensive intracranial hemorrhage and whole-cerebral hypoplasia due to latent maternal vitamin K deficiency

Goto, T., Kakita, H., Takasu, M., Takeshita, S., Ueda, H., Muto, D., Kondo, T., Kurahashi, H., Okumura, A., Yamada, Y.* | JNPM 2018;

We present here a late preterm infant with extensive brain lesions resulting from vitamin K deficiency. A female infant was born after 35 weeks of gestation by emergent cesarean section because of non-reassuring fetal status. Her mother had a severe eating disorder and recurrent vomiting since early pregnancy. She was immediately intubated and ventilated because she was extremely pale, hypotonic, and non-reactive. Cerebral magnetic resonance imaging immediately after birth showed intraparenchymal hemorrhage in the left frontal lobe and cerebellum, marked cerebral edema, and cerebellar hypoplasia. Coagulation studies of the infant showed hepaplastin test <5%, prolonged PT and APTT, and a marked elevation of protein induced by vitamin K absence or antagonist-II. This case highlighted a potential risk of intracranial bleeding due to maternal vitamin K deficiency and difficulty in its prediction before delivery. Vitamin K supplementation to high-risk mothers might be indispensable for preventing severe fetal vitamin K deficiency. Even when coagulation studies in mothers is normal, it is imperative to provide vitamin K supplementation for total protection. 

*Corresponding Author: 

Yasumasa Yamada MD, PhD, Department of Perinatal and Neonatal Medicine Aichi Medical University, 1-1 Yazako, Karimata, Nagakute, Aichi, 480-1195, Japan. Tel.: +81 561 62 3311; Fax: +81 561 61 1864; E-mail: yamasan@aichi-med-u.ac.jp.