Abstract. A term infant developed seizure activity, irritability, jitteriness, hypertonia and irregular breathing after delivery, following maternal fluoxetine use during the third trimester of pregnancy. An electroencephalogram (EEG) demonstrated changes consistent with mild cerebral dysfunction. Adverse neurological signs in the newborn infant following third trimester selective serotonin reuptake inhibitor (SSRI) exposure have been previously reported. This is the first report of directly observed changes in cerebral function at EEG. This finding has implications for the treatment of depression in pregnancy and neurological follow-up of infants exposed to SSRIs in-utero.