Management of mixed type congenital mesoblastic nephroma: Case series and review of the literature

J. Daniel IV*, A.Ruzic , J. Dalland , V. Miller, M. Hanna | JNPM 2017;


Congenital mesoblastic nephroma (CMN) is the most common renal tumor of infancy; however, it occurs infrequently with an incidence of 1 : 125,000. The cellular and classical variants are the most common subtypes of tumors, with a mixed variant occurring infrequently. We describe two cases of mixed variant CMN, which presented within days of each other differing in their clinical behavior. The first case followed a typical course, previously described in the literature, while the other deviated significantly. Traditionally, CMN presents as large abdominal mass in the neonatal period associated with a paraneoplastic syndrome, which can result in hypertension or hypercalcemia. Surgical resection is curative in most cases and long-term prognosis is excellent. Hypertension rarely persists after removal of the tumor, but remained in one of our two patients.

*Corresponding Author: 

John Daniel, IV, MD, Department of Pediatrics, Division on Neonatology, 138 Leader Avenue, Suite 009, Lexington, KY 40536, USA. Tel.: +1 859 323 1496; E-mail: