Neonatal complex arrhythmias possibly related to a TTN mutation

W.N. Evans*, R.J. Acherman, I.H. Law, N.H. Von Bergen, R.A. Samson, A. Ricardo, H. Restrepo | JNPM 2017;

We describe a neonate born with complex arrhythmias that included concurrent atrial and ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN gene, which codes for titin, a large protein found in striated muscle sarcomeres. The complex arrhythmias were successfully treated with amiodarone and flecainide. The patient remains asymptomatic with normal biventricular function. We speculate that the complex arrhythmias and TTN gene mutation may be related.

*Corresponding Author: 

William N. Evans, MD., Children’s Heart Center Nevada, 3006 S. Maryland Pkwy, Ste. 690, Las Vegas, NV 89109, USA. Tel.: +1 702 732 1290; Fax: +1 702 732 1385; E-mail: wnevans50@aol.